Recent Publications

SARS-CoV-2

Cianfarini C, Hassler L, Wysocki J, Hassan A, Nicolaescu V, Elli D, Gula H, Ibrahim AM, Randall G, Henkin J, Batlle D. Soluble Angiotensin-Converting Enzyme 2 Protein Improves Survival and Lowers Viral Titers in Lethal Mouse Model of Severe Acute Respiratory Syndrome Coronavirus Type 2 Infection with the Delta Variant. Cells. 2024 Jan 23;13(3):203. doi: 10.3390/cells13030203. PMID: 38334597; PMCID: PMC10854654.

Asiedu SO, Gupta Y, Nicolaescu V, Gula H, Caulfield TR, Durvasula R, Kempaiah P, Kwofie SK, Wilson MD. Mycolactone: A Broad Spectrum Multitarget Antiviral Active in the Picomolar Range for COVID-19 Prevention and Cure. Int J Mol Sci. 2023 Apr 12;24(8):7151. doi: 10.3390/ijms24087151. PMID: 37108313; PMCID: PMC10139166.

Hassler L, Wysocki J, Ahrendsen JT, Ye M, Gelarden I, Nicolaescu V, Tomatsidou A, Gula H, Cianfarini C, Forster P, Khurram N, Singer BD, Randall G, Missiakas D, Henkin J, Batlle D. Intranasal soluble ACE2 improves survival and prevents brain SARS-CoV-2 infection. Life Sci Alliance. 2023 Apr 11;6(7):e202301969. doi: 10.26508/lsa.202301969. PMID: 37041017; PMCID: PMC10098141.

Mohammad TSH, Gupta Y, Reidl CT, Nicolaescu V, Gula H, Durvasula R, Kempaiah P, Becker DP. In Silico Binding of 2-Aminocyclobutanones to SARS-CoV-2 Nsp13 Helicase and Demonstration of Antiviral Activity. Int J Mol Sci. 2023 Mar 7;24(6):5120. doi: 10.3390/ijms24065120. PMID: 36982188; PMCID: PMC10049026.

Zhou Y, Liu Y, Gupta S, Paramo MI, Hou Y, Mao C, Luo Y, Judd J, Wierbowski S, Bertolotti M, Nerkar M, Jehi L, Drayman N, Nicolaescu V, Gula H, Tay S, Randall G, Wang P, Lis JT, Feschotte C, Erzurum SC, Cheng F, Yu H. A comprehensive SARS-CoV-2-human protein-protein interactome reveals COVID-19 pathobiology and potential host therapeutic targets. Nat Biotechnol. 2023 Jan;41(1):128-139. doi: 10.1038/s41587-022-01474-0. Epub 2022 Oct 10. PMID: 36217030; PMCID: PMC9851973.

Nguyen LC, Renner DM, Silva D, Yang D, Parenti NA, Medina KM, Nicolaescu V, Gula H, Drayman N, Valdespino A, Mohamed A, Dann C, Wannemo K, Robinson-Mailman L, Gonzalez A, Stock L, Cao M, Qiao Z, Moellering RE, Tay S, Randall G, Beers MF, Rosner MR, Oakes SA, Weiss SR. SARS-CoV-2 Diverges from Other Betacoronaviruses in Only Partially Activating the IRE1α/XBP1 Endoplasmic Reticulum Stress Pathway in Human Lung-Derived Cells. mBio. 2022 Oct 26;13(5):e0241522. doi: 10.1128/mbio.02415-22. Epub 2022 Sep 20. PMID: 36125275; PMCID: PMC9600248.

Lian Q, Zhang K, Zhang Z, Duan F, Guo L, Luo W, Mok BW, Thakur A, Ke X, Motallebnejad P, Nicolaescu V, Chen J, Ma CY, Zhou X, Han S, Han T, Zhang W, Tan AY, Zhang T, Wang X, Xu D, Xiang J, Xu A, Liao C, Huang FP, Chen YW, Na J, Randall G, Tse HF, Chen Z, Chen Y, Chen HJ. Differential effects of macrophage subtypes on SARS-CoV-2 infection in a human pluripotent stem cell-derived model. Nat Commun. 2022 Apr 19;13(1):2028. doi: 10.1038/s41467-022-29731-5. PMID: 35440562; PMCID: PMC9018716.

Teplensky MH, Distler ME, Kusmierz CD, Evangelopoulos M, Gula H, Elli D, Tomatsidou A, Nicolaescu V, Gelarden I, Yeldandi A, Batlle D, Missiakas D, Mirkin CA. Spherical nucleic acids as an infectious disease vaccine platform. Proc Natl Acad Sci U S A. 2022 Apr 5;119(14):e2119093119. doi: 10.1073/pnas.2119093119. Epub 2022 Mar 21. PMID: 35312341; PMCID: PMC9168922.

Hassler L, Wysocki J, Gelarden I, Sharma I, Tomatsidou A, Ye M, Gula H, Nicoleascu V, Randall G, Pshenychnyi S, Khurram N, Kanwar Y, Missiakas D, Henkin J, Yeldandi A, Batlle D. A Novel Soluble ACE2 Protein Provides Lung and Kidney Protection in Mice Susceptible to Lethal SARS-CoV-2 Infection. J Am Soc Nephrol. 2022 Jul;33(7):1293-1307. doi: 10.1681/ASN.2021091209. Epub 2022 Mar 2. PMID: 35236774; PMCID: PMC9257820.

Nguyen LC, Yang D, Nicolaescu V, Best TJ, Gula H, Saxena D, Gabbard JD, Chen SN, Ohtsuki T, Friesen JB, Drayman N, Mohamed A, Dann C, Silva D, Robinson-Mailman L, Valdespino A, Stock L, Suárez E, Jones KA, Azizi SA, Demarco JK, Severson WE, Anderson CD, Millis JM, Dickinson BC, Tay S, Oakes SA, Pauli GF, Palmer KE; National COVID Cohort Collaborative Consortium; Meltzer DO, Randall G, Rosner MR. Cannabidiol inhibits SARS-CoV-2 replication through induction of the host ER stress and innate immune responses. Sci Adv. 2022 Feb 25;8(8):eabi6110. doi: 10.1126/sciadv.abi6110. Epub 2022 Feb 23. PMID: 35050692.

Missiakas Lab

Ibrahim AM, Azam MS, Schneewind O, Missiakas D. Processing of LtaS restricts LTA assembly and YSIRK preprotein trafficking into Staphylococcus aureus cross-walls. mBio. 2024 Jan 4; Epub ahead of print. PMID: 38174934.

Bernardino, P. N., Bhattacharya, M., Chen, X., Jenkins, J., Missiakas, D., & Thammavongsa, V. (2023). A humanized monoclonal antibody targeting protein a promotes opsonophagocytosis of Staphylococcus aureus in human umbilical cord blood. Vaccine, 41(35), 5079-5084.

Bobrovskyy, M., Chen, X., & Missiakas, D. (2023). The Type 7b Secretion System of S. aureus and Its Role in Colonization and Systemic Infection. Infection and Immunity, e00015-23.

Chen, X., Gula, H., Pius, T., Ou, C., Gomozkova, M., Wang, L. X., … & Missiakas, D. (2023). Immunoglobulin G subclasses confer protection against Staphylococcus aureus bloodstream dissemination through distinct mechanisms in mouse models. Proceedings of the National Academy of Sciences, 120(14), e2220765120.

Oh, S. Y., Chateau, A., Tomatsidou, A., Elli, D., Gula, H., Schneewind, O., & Missiakas, D. (2023). Modeling gastrointestinal anthrax disease. Research in Microbiology, 104026.

Chen Lab

Mullins B, Chen J. NLRP9 in innate immunity and inflammation. Immunology. 2021 Mar;162(3):262-267. doi: 10.1111/imm.13290. Epub 2020 Dec 20. PMID: 33283292; PMCID: PMC7884643.

Khader Lab

Das S, Chauhan KS, Ahmed M, Akter S, Lu L, Colonna M, Khader SA. Lung type 3 innate lymphoid cells respond early following Mycobacterium tuberculosis infection. mBio. 2024 Feb 26:e0329923. doi: 10.1128/mbio.03299-23. Epub ahead of print. PMID: 38407132.

Chauhan KS, Dunlap MD, Akter S, Gupta A, Ahmed M, Rosa BA, Dela Peña NB, Mitreva M, Khader SA. NF-κB signaling deficiency in CD11c-expressing phagocytes mediates early inflammatory responses and enhances Mycobacterium tuberculosis control. J Infect Dis. 2024 Feb 7:jiae060. doi: 10.1093/infdis/jiae060. Epub ahead of print. PMID: 38324907.

Ahmed M, Farris E, Swanson RV, Das S, Yang Y, Martin T, Khader SA. Saponin TQL1055 adjuvant-containing vaccine confers protection upon Mycobacterium tuberculosis challenge in mice. Hum Vaccin Immunother. 2024 Dec 31;20(1):2302070. doi: 10.1080/21645515.2024.2302070. Epub 2024 Jan 8. PMID: 38190806; PMCID: PMC10793695.

Mellett L, Amarasinghe G, Farnsworth CW, Khader SA. Elevated Level of Circulating but Not Urine S100A8/A9 Identifies Poor COVID-19 Outcomes. ACS Infect Dis. 2023 Oct 13;9(10):1815-1820. doi: 10.1021/acsinfecdis.3c00249. Epub 2023 Oct 3. PMID: 37787461; PMCID: PMC10580308.

Bobba S, Howard NC, Das S, Ahmed M, Khan N, Marchante I, Barreiro LB, Sanz J, Divangahi M, Khader SA. Mycobacterium tuberculosis infection drives differential responses in the bone marrow hematopoietic stem and progenitor cells. Infect Immun. 2023 Oct 17;91(10):e0020123. doi: 10.1128/iai.00201-23. Epub 2023 Sep 27. PMID: 37754680; PMCID: PMC10580947.

Bobba S, Howard NC, Das S, Ahmed M, Tang L, Thirunavukkarasu S, Larsen MH, Mathema B, Divangahi M, Khader SA. Mycobacterium tuberculosis carrying the rifampicin drug-resistance-conferring rpoB mutation H445Y is associated with suppressed immunity through type I interferons. mBio. 2023 Oct 31;14(5):e0094623. doi: 10.1128/mbio.00946-23. Epub 2023 Sep 8. PMID: 37682004; PMCID: PMC10653897.

Randall Lab

Kurhade C, Kang S, Biering SB, Hwang S, Randall G. CAPRIN1 Is Required for Control of Viral Replication Complexes by Interferon Gamma. mBio. 2023 Jun 27;14(3):e0017223. doi: 10.1128/mbio.00172-23. Epub 2023 Apr 13. PMID: 37052473; PMCID: PMC10294620.

So CW, Sourisseau M, Sarwar S, Evans MJ, Randall G. Roles of epidermal growth factor receptor, claudin-1 and occludin in multi-step entry of hepatitis C virus into polarized hepatoma spheroids. PLoS Pathog. 2023 Dec 29;19(12):e1011887. doi: 10.1371/journal.ppat.1011887. PMID: 38157366; PMCID: PMC10756512.

Emanuelson C, Ankenbruck N, Kumbhare R, Thomas M, Connelly C, Baktash Y, Randall G, Deiters A. Transcriptional Inhibition of MicroRNA miR-122 by Small Molecules Reduces Hepatitis C Virus Replication in Liver Cells. J Med Chem. 2022 Dec 22;65(24):16338-16352. doi: 10.1021/acs.jmedchem.2c01141. Epub 2022 Nov 30. PMID: 36449366; PMCID: PMC9942140.

Schor S, Pu S, Nicolaescu V, Azari S, Kõivomägi M, Karim M, Cassonnet P, Saul S, Neveu G, Yueh A, Demeret C, Skotheim JM, Jacob Y, Randall G, Einav S. The cargo adapter protein CLINT1 is phosphorylated by the Numb-associated kinase BIKE and mediates dengue virus infection. J Biol Chem. 2022 Jun;298(6):101956. doi: 10.1016/j.jbc.2022.101956. Epub 2022 Apr 20. PMID: 35452674; PMCID: PMC9133654.