HTRL Publications

This list contains the publications from HTRL since research began in 2010.

Biosafety Level 3 Publications

Hartmann, S., Radochonski, L., Ye, C. et al. SARS-CoV-2 ORF3a drives dynamic dense body formation for optimal viral infectivity. Nat Commun 16, 4393 (2025).

Klunk, J., Vilgalys, T. P., Demeure, C. E., Cheng, X., Shiratori, M., Madej, J., Beau, R., Elli, D., Patino, M. I., Redfern, R., DeWitte, S. N., Gamble, J. A., Boldsen, J. L., Carmichael, A., Varlik, N., Eaton, K., Grenier, J. C., Golding, G. B., Devault, A., Rouillard, J. M., … Barreiro, L. B. (2025). Author Correction: Evolution of immune genes is associated with the Black DeathNature, 10.1038/s41586-024-08522-6.

Cianfarini C, Hassler L, Wysocki J, Hassan A, Nicolaescu V, Elli D, Gula H, Ibrahim AM, Randall G, Henkin J, Batlle D. Soluble Angiotensin-Converting Enzyme 2 Protein Improves Survival and Lowers Viral Titers in Lethal Mouse Model of Severe Acute Respiratory Syndrome Coronavirus Type 2 Infection with the Delta Variant. Cells. 2024 Jan 23;13(3):203. 

Oh, S. Y., Chateau, A., Tomatsidou, A., Elli, D., Gula, H., Schneewind, O., & Missiakas, D. (2023). Modeling gastrointestinal anthrax disease. Research in Microbiology, 104026.

Asiedu SO, Gupta Y, Nicolaescu V, Gula H, Caulfield TR, Durvasula R, Kempaiah P, Kwofie SK, Wilson MD. Mycolactone: A Broad Spectrum Multitarget Antiviral Active in the Picomolar Range for COVID-19 Prevention and Cure. Int J Mol Sci. 2023 Apr 12;24(8):7151.

Hassler L, Wysocki J, Ahrendsen JT, Ye M, Gelarden I, Nicolaescu V, Tomatsidou A, Gula H, Cianfarini C, Forster P, Khurram N, Singer BD, Randall G, Missiakas D, Henkin J, Batlle D. Intranasal soluble ACE2 improves survival and prevents brain SARS-CoV-2 infection. Life Sci Alliance. 2023 Apr 11;6(7):e202301969. 

Mohammad TSH, Gupta Y, Reidl CT, Nicolaescu V, Gula H, Durvasula R, Kempaiah P, Becker DP. In Silico Binding of 2-Aminocyclobutanones to SARS-CoV-2 Nsp13 Helicase and Demonstration of Antiviral Activity. Int J Mol Sci. 2023 Mar 7;24(6):5120. 

Zhou Y, Liu Y, Gupta S, Paramo MI, Hou Y, Mao C, Luo Y, Judd J, Wierbowski S, Bertolotti M, Nerkar M, Jehi L, Drayman N, Nicolaescu V, Gula H, Tay S, Randall G, Wang P, Lis JT, Feschotte C, Erzurum SC, Cheng F, Yu H. A comprehensive SARS-CoV-2-human protein-protein interactome reveals COVID-19 pathobiology and potential host therapeutic targets. Nat Biotechnol. 2023 Jan;41(1):128-139. Epub 2022 Oct 10.

Nguyen LC, Renner DM, Silva D, Yang D, Parenti NA, Medina KM, Nicolaescu V, Gula H, Drayman N, Valdespino A, Mohamed A, Dann C, Wannemo K, Robinson-Mailman L, Gonzalez A, Stock L, Cao M, Qiao Z, Moellering RE, Tay S, Randall G, Beers MF, Rosner MR, Oakes SA, Weiss SR. SARS-CoV-2 Diverges from Other Betacoronaviruses in Only Partially Activating the IRE1α/XBP1 Endoplasmic Reticulum Stress Pathway in Human Lung-Derived Cells. mBio. 2022 Oct 26;13(5):e0241522. 

Lian Q, Zhang K, Zhang Z, Duan F, Guo L, Luo W, Mok BW, Thakur A, Ke X, Motallebnejad P, Nicolaescu V, Chen J, Ma CY, Zhou X, Han S, Han T, Zhang W, Tan AY, Zhang T, Wang X, Xu D, Xiang J, Xu A, Liao C, Huang FP, Chen YW, Na J, Randall G, Tse HF, Chen Z, Chen Y, Chen HJ. Differential effects of macrophage subtypes on SARS-CoV-2 infection in a human pluripotent stem cell-derived model. Nat Commun. 2022 Apr 19;13(1):2028. 

Teplensky MH, Distler ME, Kusmierz CD, Evangelopoulos M, Gula H, Elli D, Tomatsidou A, Nicolaescu V, Gelarden I, Yeldandi A, Batlle D, Missiakas D, Mirkin CA. Spherical nucleic acids as an infectious disease vaccine platform. Proc Natl Acad Sci U S A. 2022 Apr 5;119(14):e2119093119. 

Hassler L, Wysocki J, Gelarden I, Sharma I, Tomatsidou A, Ye M, Gula H, Nicoleascu V, Randall G, Pshenychnyi S, Khurram N, Kanwar Y, Missiakas D, Henkin J, Yeldandi A, Batlle D. A Novel Soluble ACE2 Protein Provides Lung and Kidney Protection in Mice Susceptible to Lethal SARS-CoV-2 Infection. J Am Soc Nephrol. 2022 Jul;33(7):1293-1307.

Chateau, A., Oh, S. Y., Tomatsidou, A., Brockhausen, I., Schneewind, O., & Missiakas, D. (2020). Distinct Pathways Carry Out α and β Galactosylation of Secondary Cell Wall Polysaccharide in Bacillus anthracis. Journal of bacteriology202(15), e00191-20.

Osei-Owusu, P., Charlton, T. M., Kim, H. K., Missiakas, D., & Schneewind, O. (2019). FPR1 is the plague receptor on host immune cellsNature574(7776), 57–62. 

Chateau, A., Schneewind, O., & Missiakas, D. (2019). Extraction and Purification of Wall-Bound Polymers of Gram-Positive BacteriaMethods in molecular biology (Clifton, N.J.)1954, 47–57. 

Chateau, A., Lunderberg, J. M., Oh, S. Y., Abshire, T., Friedlander, A., Quinn, C. P., Missiakas, D. M., & Schneewind, O. (2018). Galactosylation of the Secondary Cell Wall Polysaccharide of Bacillus anthracis and Its Contribution to Anthrax PathogenesisJournal of bacteriology200(5), e00562-17.

Missiakas, D., & Schneewind, O. (2017). Assembly and Function of the Bacillus anthracis S-Layer. Annual review of microbiology71, 79–98. 

Callegan, M. C., Parkunan, S. M., Randall, C. B., Coburn, P. S., Miller, F. C., LaGrow, A. L., Astley, R. A., Land, C., Oh, S. Y., & Schneewind, O. (2017). The role of pili in Bacillus cereus intraocular infection. Experimental eye research159, 69–76.

Mitchell, A., Tam, C., Elli, D., Charlton, T., Osei-Owusu, P., Fazlollahi, F., Faull, K. F., & Schneewind, O. (2017). Glutathionylation of Yersinia pestis LcrV and Its Effects on Plague PathogenesismBio8(3), e00646-17. 

Oh SY, Lunderberg JM, Chateau A, Schneewind O, Missiakas D. Genes required for Bacillus anthracis secondary cell wall polysaccharide synthesis. J Bacteriol. 2017;199(1):e00613-16. 

Liszewski Zilla, M., Lunderberg, J. M., Schneewind, O., & Missiakas, D. (2015). Bacillus anthracis lcp Genes Support Vegetative Growth, Envelope Assembly, and Spore FormationJournal of bacteriology197(23), 3731–3741. 

Lunderberg, J. M., Liszewski Zilla, M., Missiakas, D., & Schneewind, O. (2015). Bacillus anthracis tagO Is Required for Vegetative Growth and Secondary Cell Wall Polysaccharide SynthesisJournal of bacteriology197(22), 3511–3520. 

Nguyen-Mau, S. M., Oh, S. Y., Schneewind, D. I., Missiakas, D., & Schneewind, O. (2015). Bacillus anthracis SlaQ Promotes S-Layer Protein AssemblyJournal of bacteriology197(19), 3216–3227.

Oh, S. Y., Richter, S. G., Missiakas, D. M., & Schneewind, O. (2015). Glutamate Racemase Mutants of Bacillus anthracisJournal of bacteriology197(11), 1854–1861.

Liszewski Zilla, M., Chan, Y. G., Lunderberg, J. M., Schneewind, O., & Missiakas, D. (2015). LytR-CpsA-Psr enzymes as determinants of Bacillus anthracis secondary cell wall polysaccharide assemblyJournal of bacteriology197(2), 343–353. 

Tam, C., Demke, O., Hermanas, T., Mitchell, A., Hendrickx, A. P., & Schneewind, O. (2014). YfbA, a Yersinia pestis regulator required for colonization and biofilm formation in the gut of cat fleasJournal of bacteriology196(6), 1165–1173. 

Wang YT, Missiakas D, Schneewind O. GneZ, a UDP-GlcNAc 2-epimerase, is required for S-layer assembly and vegetative growth of Bacillus anthracis. J Bacteriol. 2014;196(16):2969-2978. 

Kopaskie, K. S., Ligtenberg, K. G., & Schneewind, O. (2013). Translational regulation of Yersinia enterocolitica mRNA encoding a type III secretion substrateThe Journal of biological chemistry288(49), 35478–35488. 

Lunderberg JM, Nguyen-Mau SM, Richter GS, Wang YT, Dworkin J, Missiakas DM, Schneewind O. Bacillus anthracis acetyltransferases PatA1 and PatA2 modify the secondary cell wall polysaccharide and affect the assembly of S-layer proteins. J Bacteriol. 2013;195(20):4650-4659.

Oh SY, Maier H, Schroeder J, Richter GS, Elli D, Musser JM, Quenee LE, Missiakas DM, Schneewind O. Vaccine protection against Bacillus cereus-mediated respiratory anthrax-like disease in mice. Infect Immun. 2013;81(3):1008-1017. 

Lunderberg, J. M., Nguyen-Mau, S. M., Richter, G. S., Wang, Y. T., Dworkin, J., Missiakas, D. M., & Schneewind, O. (2013). Bacillus anthracis acetyltransferases PatA1 and PatA2 modify the secondary cell wall polysaccharide and affect the assembly of S-layer proteinsJournal of bacteriology195(5), 977–989. 

Ligtenberg, K. G., Miller, N. C., Mitchell, A., Plano, G. V., & Schneewind, O. (2013). LcrV mutants that abolish Yersinia type III injectisome functionJournal of bacteriology195(4), 777–787. 

Wang, Y. T., Oh, S. Y., Hendrickx, A. P., Lunderberg, J. M., & Schneewind, O. (2013). Bacillus cereus G9241 S-layer assembly contributes to the pathogenesis of anthrax-like disease in miceJournal of bacteriology195(3), 596–605. 

Quenee, L. E., Hermanas, T. M., Ciletti, N., Louvel, H., Miller, N. C., Elli, D., Blaylock, B., Mitchell, A., Schroeder, J., Krausz, T., Kanabrocki, J., & Schneewind, O. (2012). Hereditary hemochromatosis restores the virulence of plague vaccine strainsThe Journal of infectious diseases206(7), 1050–1058. 

Garufi, G., Hendrickx, A. P., Beeri, K., Kern, J. W., Sharma, A., Richter, S. G., Schneewind, O., & Missiakas, D. (2012). Synthesis of lipoteichoic acids in Bacillus anthracisJournal of bacteriology194(16), 4312–4321. 

Kern, V. J., Kern, J. W., Theriot, J. A., Schneewind, O., & Missiakas, D. (2012). Surface-layer (S-layer) proteins sap and EA1 govern the binding of the S-layer-associated protein BslO at the cell septa of Bacillus anthracisJournal of bacteriology194(15), 3833–3840. 

Nguyen-Mau, S. M., Oh, S. Y., Kern, V. J., Missiakas, D. M., & Schneewind, O. (2012). Secretion genes as determinants of Bacillus anthracis chain lengthJournal of bacteriology194(15), 3841–3850.

Tonry, J. H., McNichol, B. A., Ramarao, N., Chertow, D. S., Kim, K. S., Stibitz, S., Schneewind, O., Kashanchi, F., Bailey, C. L., Popov, S., & Chung, M. C. (2012). Bacillus anthracis protease InhA regulates BslA-mediated adhesion in human endothelial cellsCellular microbiology14(8), 1219–1230. 

Hendrickx, A. P., Poor, C. B., Jureller, J. E., Budzik, J. M., He, C., & Schneewind, O. (2012). Isopeptide bonds of the major pilin protein BcpA influence pilus structure and bundle formation on the surface of Bacillus cereusMolecular microbiology85(1), 152–163.

Garufi, G., Wang, Y. T., Oh, S. Y., Maier, H., Missiakas, D. M., & Schneewind, O. (2012). Sortase-conjugation generates a capsule vaccine that protects guinea pigs against Bacillus anthracisVaccine30(23), 3435–3444. 

Miller, N. C., Quenee, L. E., Elli, D., Ciletti, N. A., & Schneewind, O. (2012). Polymorphisms in the lcrV gene of Yersinia enterocolitica and their effect on plague protective immunityInfection and immunity80(4), 1572–1582. 

Houppert, A. S., Kwiatkowski, E., Glass, E. M., DeBord, K. L., Merritt, P. M., Schneewind, O., & Marketon, M. M. (2012). Identification of chromosomal genes in Yersinia pestis that influence type III secretion and delivery of Yops into target cellsPloS one7(3), e34039. 

Wright, A. M., Beres, S. B., Consamus, E. N., Long, S. W., Flores, A. R., Barrios, R., Richter, G. S., Oh, S. Y., Garufi, G., Maier, H., Drews, A. L., Stockbauer, K. E., Cernoch, P., Schneewind, O., Olsen, R. J., & Musser, J. M. (2011). Rapidly progressive, fatal, inhalation anthrax-like infection in a human: case report, pathogen genome sequencing, pathology, and coordinated responseArchives of pathology & laboratory medicine135(11), 1447–1459. 

Quenee, L. E., Ciletti, N. A., Elli, D., Hermanas, T. M., & Schneewind, O. (2011). Prevention of pneumonic plague in mice, rats, guinea pigs and non-human primates with clinical grade rV10, rV10-2 or F1-V vaccinesVaccine29(38), 6572–6583.

Kern, J., Wilton, R., Zhang, R., Binkowski, T. A., Joachimiak, A., & Schneewind, O. (2011). Structure of surface layer homology (SLH) domains from Bacillus anthracis surface array protein. The Journal of biological chemistry286(29), 26042–26049. 

Anderson, V. J., Kern, J. W., McCool, J. W., Schneewind, O., & Missiakas, D. (2011). The SLH-domain protein BslO is a determinant of Bacillus anthracis chain lengthMolecular microbiology81(1), 192–205. 

Frank, K. M., Schneewind, O., & Shieh, W. J. (2011). Investigation of a researcher’s death due to septicemic plagueThe New England journal of medicine364(26), 2563–2564. 

Losada, L., Varga, J. J., Hostetler, J., Radune, D., Kim, M., Durkin, S., Schneewind, O., & Nierman, W. C. (2011). Genome sequencing and analysis of Yersina pestis KIM D27, an avirulent strain exempt from select agent regulationPloS one6(4), e19054. 

Quenee, L. E., Ciletti, N., Berube, B., Krausz, T., Elli, D., Hermanas, T., & Schneewind, O. (2011). Plague in Guinea pigs and its prevention by subunit vaccinesThe American journal of pathology178(4), 1689–1700.

Oh, S. Y., Budzik, J. M., Garufi, G., & Schneewind, O. (2011). Two capsular polysaccharides enable Bacillus cereus G9241 to cause anthrax-like diseaseMolecular microbiology80(2), 455–470.

Kern, J., Ryan, C., Faull, K., & Schneewind, O. (2010). Bacillus anthracis surface-layer proteins assemble by binding to the secondary cell wall polysaccharide in a manner that requires csaB and tagO. Journal of molecular biology401(5), 757–775.

Quenee, L. E., Berube, B. J., Segal, J., Elli, D., Ciletti, N. A., Anderson, D., & Schneewind, O. (2010). Amino acid residues 196-225 of LcrV represent a plague protective epitopeVaccine28(7), 1870–1876. 

Blaylock, B., Berube, B. J., & Schneewind, O. (2010). YopR impacts type III needle polymerization in Yersinia speciesMolecular microbiology75(1), 221–229.

Kern, J., & Schneewind, O. (2010). BslA, the S-layer adhesin of B. anthracis, is a virulence factor for anthrax pathogenesisMolecular microbiology75(2), 324–332. 

Biosafety Level 2 Publications

Azam, M. S., Ibrahim, A. M., Leddy, O., Oh, S.-Y., Schneewind, O., & Missiakas, D. (2025). A SecA-associated protease modulates the extent of surface display of staphylococcal protein A. Journal of bacteriology207(4), e0052224. 

Ibrahim, A. M., & Missiakas, D. (2025). A novel polysaccharide in the envelope of S. aureus influences the septal secretion of preproteins with a YSIRK/GXXS motifJournal of bacteriology, e0047824. Advance online publication.

Leddy, O., Ibrahim, A. M., Azam, M. S., Solomon, S., Yu, W., Schneewind, O., & Missiakas, D. (2025). Screening a library of temperature-sensitive mutants to identify secretion factors in Staphylococcus aureusJournal of bacteriology, e0043324.

Ramos-León, F., Anjuwon-Foster, B. R., Anantharaman, V., Updegrove, T. B., Ferreira, C. N., Ibrahim, A. M., Tai, C. H., Kruhlak, M. J., Missiakas, D. M., Camberg, J. L., Aravind, L., & Ramamurthi, K. S. (2024). PcdA promotes orthogonal division plane selection in Staphylococcus aureusNature microbiology9(11), 2997–3012.

Almubarak, H. F., Tan, W., Hoffmann, A. D., Sun, Y., Wei, J., El-Shennawy, L., Squires, J. R., Dashzeveg, N. K., Simonton, B., Jia, Y., Iyer, R., Xu, Y., Nicolaescu, V., Elli, D., Randall, G. C., Schipma, M. J., Swaminathan, S., Ison, M. G., Liu, H., Fang, D., … Shen, Y. (2024). Novel antibody language model accelerates IgG screening and design for broad-spectrum antiviral therapy.

Chen, X., & Missiakas, D. (2024). Novel Antibody-Based Protection/Therapeutics in Staphylococcus aureusAnnual review of microbiology78(1), 425–446.

Jiang, S., Tian, Y., Nicolaescu, V., Mansurov, A., Randall, G., Tirrell, M. V., & LaBelle, J. L. (2024). The Role of Structural Flexibility in Hydrocarbon-Stapled Peptides Designed to Block Viral Infection via Human ACE2 Mimicry. Peptide science (Hoboken, N.J.)116(6), e24375.

Cullum, E., Perez-Betancourt, Y., Shi, M., Gkika, E., Schneewind, O., Missiakas, D., & Golovkina, T. (2024). Deficiency in non-classical major histocompatibility class II-like molecule, H2-O confers protection against Staphylococcus aureus in micePLoS pathogens20(6), e1012306.

Ibrahim AM, Azam MS, Schneewind O, Missiakas D. Processing of LtaS restricts LTA assembly and YSIRK preprotein trafficking into Staphylococcus aureus cross-walls. mBio. 2024 Jan 4; Epub ahead of print. PMID: 38174934.

Bernardino, P. N., Bhattacharya, M., Chen, X., Jenkins, J., Missiakas, D., & Thammavongsa, V. (2023). A humanized monoclonal antibody targeting protein a promotes opsonophagocytosis of Staphylococcus aureus in human umbilical cord bloodVaccine41(35), 5079-5084.

Bobrovskyy, M., Chen, X., & Missiakas, D. (2023). The Type 7b Secretion System of S. aureus and Its Role in Colonization and Systemic InfectionInfection and Immunity, e00015-23.

Missiakas D, Winstel V. Selective host cell death by Staphylococcus aureus: a strategy for bacterial persistence. Front Immunol. 2021;11:621733.

Chen, X., Gula, H., Pius, T., Ou, C., Gomozkova, M., Wang, L. X., … & Missiakas, D. (2023). Immunoglobulin G subclasses confer protection against Staphylococcus aureus bloodstream dissemination through distinct mechanisms in mouse modelsProceedings of the National Academy of Sciences120(14), e2220765120.

Shi, M., Chen, X., Sun, Y., Kim, H. K., Schneewind, O., & Missiakas, D. (2021). A protein A based Staphylococcus aureus vaccine with improved safetyVaccine39(29), 3907–3915. 

Willing, S., Schneewind, O., & Missiakas, D. (2021). Regulated cleavage of glycan strands by the murein hydrolase SagB in S. aureus involves a direct interaction with LyrA (SpdC)Journal of bacteriology203(9), e00014-21. 

Shi, M., Willing, S. E., Kim, H. K., Schneewind, O., & Missiakas, D. (2021). Peptidoglycan Contribution to the B Cell Superantigen Activity of Staphylococcal Protein AmBio12(2), e00039-21. 

Willing, S., Dyer, E., Schneewind, O., & Missiakas, D. (2020). FmhA and FmhC of Staphylococcus aureus incorporate serine residues into peptidoglycan cross-bridgesThe Journal of biological chemistry295(39), 13664–13676. 

Chen, X., Shi, M., Tong, X., Kim, H. K., Wang, L. X., Schneewind, O., & Missiakas, D. (2020). Glycosylation-dependent opsonophagocytic activity of staphylococcal protein A antibodies. Proceedings of the National Academy of Sciences of the United States of America117(37), 22992–23000. 

Kim, H. K., Premaratna, R., Missiakas, D. M., & Schneewind, O. (2019). Rickettsia conorii O antigen is the target of bactericidal Weil-Felix antibodies. Proceedings of the National Academy of Sciences of the United States of America116(39), 19659–19664.

Schneewind O, Missiakas DM. Staphylococcal Protein Secretion and Envelope Assembly. Microbiol Spectr. 2019 Jul;7(4):10.1128/microbiolspec.gpp3-0070-2019. doi: 10.1128/microbiolspec.GPP3-0070-2019. PMID: 31267890; PMCID: PMC7028390.

Winstel V, Schneewind O, Missiakas D. Staphylococcus aureus exploits the host apoptotic pathway to persist during infection. mBio. 2019;10(6):e02270-19.

Schneewind, O., & Missiakas, D. (2019). Sortases, Surface Proteins, and Their Roles in Staphylococcus aureus Disease and Vaccine Development. Microbiology spectrum7(1), 10.1128/microbiolspec.psib-0004-2018. 

Bobrovskyy, M., Willing, S. E., Schneewind, O., & Missiakas, D. (2018). EssH Peptidoglycan Hydrolase Enables Staphylococcus aureus Type VII Secretion across the Bacterial Cell Wall EnvelopeJournal of bacteriology200(20), e00268-18. 

Winstel V, Missiakas D, Schneewind O. Staphylococcus aureus targets the purine salvage pathway to kill phagocytes. Proc Natl Acad Sci U S A. 2018;115(26):6846-6851.

Yu, W., Missiakas, D., & Schneewind, O. (2018). Septal secretion of protein A in Staphylococcus aureus requires SecA and lipoteichoic acid synthesiseLife7, e34092.

Sun, Y., Emolo, C., Holtfreter, S., Wiles, S., Kreiswirth, B., Missiakas, D., & Schneewind, O. (2018). Staphylococcal Protein A Contributes to Persistent Colonization of Mice with Staphylococcus aureus. Journal of bacteriology200(9), e00735-17. 

Yu W, Kim HK, Rauch S, Schneewind O, Missiakas D. Pathogenic conversion of coagulase-negative staphylococci. Microbes Infect. 2017;19(2):101-109.

Ohr RJ, Anderson M, Shi M, Schneewind O, Missiakas D. EssD, a nuclease effector of the Staphylococcus aureus ESS pathway. J Bacteriol. 2017;199(1):e00528-16.

Anderson, M., Ohr, R. J., Aly, K. A., Nocadello, S., Kim, H. K., Schneewind, C. E., Schneewind, O., & Missiakas, D. (2016). EssE Promotes Staphylococcus aureus ESS-Dependent Protein Secretion To Modify Host Immune Responses during InfectionJournal of bacteriology199(1), e00527-16.

Winstel V, Kühner P, Rohde H, Peschel A, Missiakas D, Schneewind O. Genetic engineering of untransformable coagulase-negative staphylococcal pathogens. Nat Protoc. 2016;11(5):949-959. 

Missiakas, D., & Schneewind, O. (2016). Staphylococcus aureus vaccines: Deviating from the carol. The Journal of experimental medicine213(9), 1645–1653. 

Thomer L, Schneewind O, Missiakas D. (2016). Pathogenesis of Staphylococcus aureus bloodstream infections. Annu Rev Pathol, 11:343-364.

Kim HK, Falugi F, Missiakas DM, Schneewind O. Peptidoglycan-linked protein A promotes T cell-dependent antibody expansion during Staphylococcus aureus infection. Proc Natl Acad Sci U S A. 2016;113(20):5718-5723.

Thomer L, Emolo C, Thammavongsa V, Kim HK, McAdow ME, Yu W, Kieffer M, Schneewind O, Missiakas D. Antibodies against a secreted product of Staphylococcus aureus trigger phagocytic killing. J Exp Med. 2016;213(3):293-301.

Chan, Y. G., Frankel, M. B., Missiakas, D., & Schneewind, O. (2016). SagB Glucosaminidase Is a Determinant of Staphylococcus aureus Glycan Chain Length, Antibiotic Susceptibility, and Protein SecretionJournal of bacteriology198(7), 1123–1136.

Thammavongsa V, Kim HK, Missiakas D, Schneewind O. Staphylococcal manipulation of host immune responses. Nat Rev Microbiol. 2015 Sep;13(9):529-43.  PMID: 26272408; PMCID: PMC4625792.

Bagnoli, F., Fontana, M. R., Soldaini, E., Mishra, R. P., Fiaschi, L., Cartocci, E., Nardi-Dei, V., Ruggiero, P., Nosari, S., De Falco, M. G., Lofano, G., Marchi, S., Galletti, B., Mariotti, P., Bacconi, M., Torre, A., Maccari, S., Scarselli, M., Rinaudo, C. D., Inoshima, N., … Grandi, G. (2015). Vaccine composition formulated with a novel TLR7-dependent adjuvant induces high and broad protection against Staphylococcus aureusProceedings of the National Academy of Sciences of the United States of America112(12), 3680–3685.

Thammavongsa, V., Rauch, S., Kim, H. K., Missiakas, D. M., & Schneewind, O. (2015). Protein A-neutralizing monoclonal antibody protects neonatal mice against Staphylococcus aureusVaccine33(4), 523–526.

Kim, H. K., Falugi, F., Thomer, L., Missiakas, D. M., & Schneewind, O. (2015). Protein A suppresses immune responses during Staphylococcus aureus bloodstream infection in guinea pigsmBio6(1), e02369-14. 

Pauli, N. T., Kim, H. K., Falugi, F., Huang, M., Dulac, J., Henry Dunand, C., Zheng, N. Y., Kaur, K., Andrews, S. F., Huang, Y., DeDent, A., Frank, K. M., Charnot-Katsikas, A., Schneewind, O., & Wilson, P. C. (2014). Staphylococcus aureus infection induces protein A-mediated immune evasion in humansThe Journal of experimental medicine211(12), 2331–2339. 

Rauch S, Gough P, Kim HK, Schneewind O, Missiakas D. Vaccine protection of leukopenic mice against Staphylococcus aureus bloodstream infection. Infect Immun. 2014;82(11):4889-4898. 

Kim HK, Missiakas D, Schneewind O. Mouse models for infectious diseases caused by Staphylococcus aureus. J Immunol Methods. 2014;410:88-99. 

Schneewind, O., & Missiakas, D. (2014). Sec-secretion and sortase-mediated anchoring of proteins in Gram-positive bacteriaBiochimica et biophysica acta1843(8), 1687–1697. 

Chan YG, Kim HK, Schneewind O, Missiakas D. The capsular polysaccharide of Staphylococcus aureus is attached to peptidoglycan by the LytR-CpsA-Psr (LCP) family of enzymes. J Biol Chem. 2014;289(22):15680-15690.

Becker S, Frankel MB, Schneewind O, Missiakas D. Release of protein A from the cell wall of Staphylococcus aureus. Proc Natl Acad Sci U S A. 2014;111(5):1574-1579.

Schneewind, O., & Missiakas, D. (2014). Lipoteichoic acids, phosphate-containing polymers in the envelope of gram-positive bacteria. Journal of bacteriology196(6), 1133–1142.

Schneewind, O., & Missiakas, D. (2014). Genetic manipulation of Staphylococcus aureusCurrent protocols in microbiology32, Unit–9C.3.

Thammavongsa, V., Missiakas, D. M., & Schneewind, O. (2013). Staphylococcus aureus degrades neutrophil extracellular traps to promote immune cell deathScience (New York, N.Y.)342(6160), 863–866. 

Chen, C., Krishnan, V., Macon, K., Manne, K., Narayana, S. V., & Schneewind, O. (2013). Secreted proteases control autolysin-mediated biofilm growth of Staphylococcus aureusThe Journal of biological chemistry288(41), 29440–29452. 

Thomer, L., Schneewind, O., & Missiakas, D. (2013). Multiple ligands of von Willebrand factor-binding protein (vWbp) promote Staphylococcus aureus clot formation in human plasmaThe Journal of biological chemistry288(39), 28283–28292.

Falugi, F., Kim, H. K., Missiakas, D. M., & Schneewind, O. (2013). Role of protein A in the evasion of host adaptive immune responses by Staphylococcus aureusmBio4(5), e00575-13.

Richter SG, Elli D, Kim HK, Hendrickx AP, Sorg JA, Schneewind O, Missiakas D. Small molecule inhibitor of lipoteichoic acid synthesis is an antibiotic for Gram-positive bacteria. Proc Natl Acad Sci U S A. 2013;110(9):3531-3536.

Missiakas, D. M., & Schneewind, O. (2013). Growth and laboratory maintenance of Staphylococcus aureusCurrent protocols in microbiologyChapter 9, Unit–9C.1. 

Chan YG, Frankel MB, Dengler V, Schneewind O, Missiakas D. Staphylococcus aureus mutants lacking the LytR-CpsA-Psr family of enzymes release cell wall teichoic acids into the extracellular medium. J Bacteriol. 2013;195(20):4650-4659.

Kim, H. K., Emolo, C., DeDent, A. C., Falugi, F., Missiakas, D. M., & Schneewind, O. (2012). Protein A-specific monoclonal antibodies and prevention of Staphylococcus aureus disease in miceInfection and immunity80(10), 3460–3470. 

McAdow, M., DeDent, A. C., Emolo, C., Cheng, A. G., Kreiswirth, B. N., Missiakas, D. M., & Schneewind, O. (2012). Coagulases as determinants of protective immune responses against Staphylococcus aureusInfection and immunity80(10), 3389–3398.

Rauch, S., DeDent, A. C., Kim, H. K., Bubeck Wardenburg, J., Missiakas, D. M., & Schneewind, O. (2012). Abscess formation and alpha-hemolysin induced toxicity in a mouse model of Staphylococcus aureus peritoneal infectionInfection and immunity80(10), 3721–3732. 

Schneewind, O., & Missiakas, D. M. (2012). Protein secretion and surface display in Gram-positive bacteria. Philosophical transactions of the Royal Society of London. Series B, Biological sciences367(1592), 1123–1139. 

Frankel, M. B., & Schneewind, O. (2012). Determinants of murein hydrolase targeting to cross-wall of Staphylococcus aureus peptidoglycanThe Journal of biological chemistry287(13), 10460–10471. 

DeDent, A., Kim, H. K., Missiakas, D., & Schneewind, O. (2012). Exploring Staphylococcus aureus pathways to disease for vaccine development. Seminars in immunopathology34(2), 317–333. 

Kim, H. K., Thammavongsa, V., Schneewind, O., & Missiakas, D. (2012). Recurrent infections and immune evasion strategies of Staphylococcus aureusCurrent opinion in microbiology15(1), 92–99. 

McAdow, M., Missiakas, D. M., & Schneewind, O. (2012). Staphylococcus aureus secretes coagulase and von Willebrand factor binding protein to modify the coagulation cascade and establish host infectionsJournal of innate immunity4(2), 141–148. 

Vanassche, T., Verhaegen, J., Peetermans, W. E., VAN Ryn, J., Cheng, A., Schneewind, O., Hoylaerts, M. F., & Verhamme, P. (2011). Inhibition of staphylothrombin by dabigatran reduces Staphylococcus aureus virulenceJournal of thrombosis and haemostasis : JTH9(12), 2436–2446. 

Thammavongsa, V., Schneewind, O., & Missiakas, D. M. (2011). Enzymatic properties of Staphylococcus aureus adenosine synthase (AdsA)BMC biochemistry12, 56. 

McAdow, M., Kim, H. K., Dedent, A. C., Hendrickx, A. P., Schneewind, O., & Missiakas, D. M. (2011). Preventing Staphylococcus aureus sepsis through the inhibition of its agglutination in bloodPLoS pathogens7(10), e1002307. 

Kim, H. K., Kim, H. Y., Schneewind, O., & Missiakas, D. (2011). Identifying protective antigens of Staphylococcus aureus, a pathogen that suppresses host immune responsesFASEB journal : official publication of the Federation of American Societies for Experimental Biology25(10), 3605–3612. 

Frankel, M. B., Hendrickx, A. P., Missiakas, D. M., & Schneewind, O. (2011). LytN, a murein hydrolase in the cross-wall compartment of Staphylococcus aureus, is involved in proper bacterial growth and envelope assembly. The Journal of biological chemistry286(37), 32593–32605.

Cheng, A. G., DeDent, A. C., Schneewind, O., & Missiakas, D. (2011). A play in four acts: Staphylococcus aureus abscess formationTrends in microbiology19(5), 225–232. 

Hendrickx, A. P., Budzik, J. M., Oh, S. Y., & Schneewind, O. (2011). Architects at the bacterial surface – sortases and the assembly of pili with isopeptide bondsNature reviews. Microbiology9(3), 166–176.

Frankel, M. B., Wojcik, B. M., DeDent, A. C., Missiakas, D. M., & Schneewind, O. (2010). ABI domain-containing proteins contribute to surface protein display and cell division in Staphylococcus aureusMolecular microbiology78(1), 238–252. 

Kennedy, A. D., Bubeck Wardenburg, J., Gardner, D. J., Long, D., Whitney, A. R., Braughton, K. R., Schneewind, O., & DeLeo, F. R. (2010). Targeting of alpha-hemolysin by active or passive immunization decreases severity of USA300 skin infection in a mouse modelThe Journal of infectious diseases202(7), 1050–1058.

Kim, H. K., DeDent, A., Cheng, A. G., McAdow, M., Bagnoli, F., Missiakas, D. M., & Schneewind, O. (2010). IsdA and IsdB antibodies protect mice against Staphylococcus aureus abscess formation and lethal challengeVaccine28(38), 6382–6392. 

Kim, H. K., Cheng, A. G., Kim, H. Y., Missiakas, D. M., & Schneewind, O. (2010). Nontoxigenic protein A vaccine for methicillin-resistant Staphylococcus aureus infections in miceThe Journal of experimental medicine207(9), 1863–1870. 

Cheng, A. G., McAdow, M., Kim, H. K., Bae, T., Missiakas, D. M., & Schneewind, O. (2010). Contribution of coagulases towards Staphylococcus aureus disease and protective immunityPLoS pathogens6(8), e1001036.